Alan,

...sokaparidevadukkhadomanassu[compound] (all of) this sorrow, lamentation,

> physical and mental distress
>
> paayaasaa[paay I/] proceed ?
>
> sambhavanti. [sam減 I/pres act/ 3rd pl] they are arisen
>

The word is upaayaasaa, which CPD defines as "irritation, trouble, despair". Look up
for citations.
Decide for yourself what English translation fits best.

Despite what the experts may suggest, ultimately you have to decide what it really
means to you in the context of the early teachings. Your own practice will in the end
guide you.

Sukhi

Piya